Biomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to select one method that is appropriate for their experimental conditions among nearly 50 available. https://ift.tt/eA8V8J https://ift.tt/3mKHOdy
Latest
- Researchers generate human-monkey chimeric embryos
- Scientists program microalgae’s ‘oil factory’ to produce various oils
- Programming proteins to turn cells into molecular computers
- Better understanding of fundamental cell behavior can improve drug development
- New method of artificially creating genetic switches for yeast
Scaling up genome editing in tiny worms
Understanding the effects of specific mutations in gene regulatory regions—the sections of DNA and RNA that turn genes on and off—is important to unraveling how the genome works, as well as normal development and disease. But studying a large variety of mutations in these regulatory regions in a systematic way is a monumental task. While […]
RNA interference/Gene silencing
What is RNA interference (RNAi): RNA interference (RNAi) is one of the most exciting discoveries of the past decade in functional genomics. RNAi is rapidly becoming an important method for analyzing gene functions in eukaryotes and holds promise for the development of therapeutic gene silencing. RNA interference is a novel gene regulatory mechanism that limits […]
Technique allows mapping of epigenetic information in single cells at scale
Histones are tiny proteins that bind to DNA and hold information that can help turn on or off individual genes. Researchers at Karolinska Institutet have developed a technique that makes it possible to examine how different versions of histones bind to the genome in tens of thousands of individual cells at the same time. The […]
Animals immortalized in 3D by affordable scanner technology
A new 3D scanner, which photographs small animal specimens in meticulous detail, is also being used to teach computers how to spot and track critters. https://ift.tt/eA8V8J https://ift.tt/3mGmWnT
For tomato genes, one plus one doesn’t always make two
Both people and tomatoes come in different shapes and sizes. That is because every individual has a unique set of genetic variations—mutations—that affect how genes act and function. Added together, millions of small genetic variations make it hard to predict how a particular mutation will impact any individual. Cold Spring Harbor Laboratory (CSHL) Professor and […]
Speeding up sequence alignment across the tree of life
A team of researchers from the Max Planck Institutes of Developmental Biology in Tübingen and the Max Planck Computing and Data Facility in Garching develops new search capabilities that will allow to compare the biochemical makeup of different species from across the tree of life. Its combination of accuracy and speed is hitherto unrivaled. https://ift.tt/eA8V8J […]
6 common annotation mistakes you’re likely making
Katie Azevedo, M.Ed. Below, I share 6 common annotation mistakes I see students make all the time when reading and marking up text. Check to see if you’re making any of these mistakes, and then follow the solutions I give for up-leveling your annotation game. Common annotation mistakes and how to fix them 1. Not […]
Single cell sequencing unravels molecular identity of rare renal cell types
Jaakko Patrakka and his research group at the Department of Laboratory Medicine have together with Professor Rickard Sandberg’s group at the Department of Cell and Molecular Biology got a publication accepted in Nature Communications about single cell sequencing unravels molecular identity of rare renal cell types. https://ift.tt/eA8V8J https://ift.tt/3dcOM8l
Understudied mutations have big impact on gene expression
An international team of researchers led by computer scientists at the University of California San Diego have identified 163 variable number tandem repeats (VNTRs) that actively regulate gene expression. In a paper published in Nature Communications this week, the researchers provide new insights into this understudied mechanism, how it may drive disease and other traits […]